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Candesartan ester in the body quickly is hydrolyzed into active metabolite candesartan. So, guangdong candesartan ester the pharmacological effects of is what? Toxic side effects?

Guangdong candesartan ester of angiotensin II AT1 receptor antagonist, by combined with vascular smooth muscle of AT1 receptor antagonist of angiotensin II vasoconstriction, reducing peripheral vascular resistance. Otherwise that candesartan ester can inhibit the adrenal glands secrete aldosterone and play a certain antihypertensive effect.

Experiment shows that: in patients with high blood pressure patients take candesartan ester tablet can cause many times of plasma renin activity and angiotensin I concentration and angiotensin II levels; Guangdong candesartan ester 2-8 mg once daily continuous administration, can make the systolic pressure, diastolic pressure drops, left ventricular myocardial weight, peripheral vascular resistance decreased, and the central discharge, ejection fraction, renal vascular resistance, renal blood flow and glomerular filtration rate has no obvious influence; For tableland onset hypertension patients with cerebrovascular disorders, can not influence the cerebral blood flow.

1. High potassium in patients taking guangdong candesartan ester, high potassium may occur.

2. The deterioration of liver function or jaundice patients taking guangdong candesartan ester, may appear the AST (GOT), elevated ALT (GPTO, gamma - GTP) made equivalent of liver dysfunction or jaundice, patients should be closely observed.

3. The patient medication may also occur in the process of agranulocytosis.

But this is just a side effect, is not toxic and side effect, and no clinical trials showed that candesartan guangdong ester toxic side effects.

Looked at the above introduction, believe everybody already knows guangdong candesartan ester of pharmacological action, if there is not understand place, can consult candesartan ester manufacturer of professional and technical personnel, must be able to solve your problem. Hope these information can help to you.

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